- Title
- Medication beliefs predict medication adherence in ambulatory patients with decompensated cirrhosis
- Creator
- Hayward, Kelly L.; Valery, Patricia C.; Irvine, Katharine M.; Powell, Elizabeth E.; Cottrell, W. Neil; Martin, Jennifer H.; Karmakar, Antara; Patel, Preya J.; Horsfall, Leigh U.; Tallis, Caroline J.; Stuart, Katherine A.; Wright, Penny L.; Smith, David D.
- Relation
- World Journal of Gastroenterology Vol. 23, Issue 40, p. 7321-7331
- Publisher Link
- http://dx.doi.org/10.3748/wjg.v23.i40.7321
- Publisher
- Baishideng Publishing Group
- Resource Type
- journal article
- Date
- 2017
- Description
- Aim: To investigate the impact of medication beliefs, illness perceptions and quality of life on medication adherence in people with decompensated cirrhosis. Methods: One hundred adults with decompensated cirrhosis completed a structured questionnaire when they attended for routine outpatient hepatology review. Measures of self-reported medication adherence (Morisky Medication Adherence Scale), beliefs surrounding medications (Beliefs about Medicines Questionnaire), perceptions of illness and medicines (Brief Illness Perception Questionnaire), and quality of life (Chronic Liver Disease Questionnaire) were examined. Clinical data were obtained via patient history and review of medical records. Least absolute shrinkage and selection operator and stepwise backwards regression techniques were used to construct the multivariable logistic regression model. Statistical significance was set at alpha = 0.05. Results: Medicat ion adherence was "High" in 42% of participants, "Medium" in 37%, and "Low" in 21%. Compared to patients with "High" adherence, those with "Medium" or "Low" adherence were more likely to report difficulty affording their medications (P < 0.001), lower perception of treatment helpfulness (P = 0.003) and stronger medication concerns relative to medication necessity beliefs (P = 0.003). People with "Low" adherence also experienced greater symptom burden and poorer quality of life, including more frequent abdominal pain (P = 0.023), shortness of breath (P = 0.030), and emotional disturbances (P = 0.050). Multivariable analysis identified having stronger medication concerns relative to necessity beliefs (Necessity-Concerns Differential = 5, OR = 3.66, 95%CI: 1.18-11.40) and more frequent shortness of breath (shortness of breath score = 3, OR = 3.87, 95%CI: 1.22-12.25) as independent predictors of "Low" adherence. Conclusion: The association between "Low" adherence and patients having strong concerns or doubting the necessity or helpfulness of their medications should be explored further given the clinical relevance.
- Subject
- medication adherence; medication beliefs; illness perceptions; quality of life; liver cirrhosis
- Identifier
- http://hdl.handle.net/1959.13/1351788
- Identifier
- uon:30772
- Identifier
- ISSN:1007-9327
- Rights
- This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
- Language
- eng
- Full Text
- Reviewed
- Hits: 13303
- Visitors: 6948
- Downloads: 397
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 1 MB | Adobe Acrobat PDF | View Details Download |